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Semaglutide/Glycine
0.25mg/week SC × 4 weeks
1.7–2.4mg/week
→ 0.5mg → 1mg → 1.7mg → 2.4mg (every 4 weeks)
2.4mg/week
Ongoing; evaluate at 16 weeks
Subcutaneous injection, abdomen/thigh/upper arm, once weekly
Glycine buffer reduces injection-site discomfort. Consider adding Ondansetron 4mg PRN for nausea during titration.
Weight weekly, fasting glucose, HbA1c, GI tolerance, thyroid nodules (if history)
⚠ Renal impairment noted — dose reduction may be required. Consult clinical judgment.
⚠ Cardiovascular history — review contraindications before initiating. Monitor BP and HR.
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